The clinical experience with ofloxacin in the treatment of sexually transmitted diseases

Article Abstract:

Sexually transmitted diseases cause extensive disease in women, and are often caused by infection with Neisseria gonorrhoeae, Chlamydia trachomatis, and Ureaplasma urealyticum. N. gonorrhoeae tends to be the most resistant, or least sensitive, to antibiotic therapy, including treatment with penicillin. Resistance to penicillin results from the bacterial production of the enzyme beta-lactamase, which breaks down the beta-lactam ring of the structure of certain antibiotics, such as penicillin. Chromosomal resistance involves the production of genetic factors that make the bacteria resistant to antibiotics. Studies have identified bacterial strains that are resistant to tetracycline and spectinomycin. The minimal inhibitory concentration (MIC) is the dose of antibiotic required to decrease bacterial growth by a certain percentage; it reflects the sensitivity of a bacteria to an antibiotic. An increase in MIC indicates increasing bacterial resistance, and studies have shown that an increase in MIC to some cephalosporins. Patients infected with both N. gonorrhoeae and C. trachomatis are usually treated with a single dose of ceftriaxone plus a tetracycline for one week. However, the fluoroquinolone antibiotic ofloxacin was recently introduced as a single agent for the treatment of mixed infections. Ofloxacin has the ability to treat infections caused by bacteria that are resistant to conventional antibiotics. Clinical trials, or human studies, examining the effectiveness of ofloxacin in treating sexually transmitted diseases, are reviewed. Clinical trials in the United States were conducted between 1984 and 1988 by the Robert Wood Johnson Pharmaceutical Institute. The world literature, published from February 1983 to February 1990, concerning aspects of ofloxacin treatment is also examined. (Consumer Summary produced by Reliance Medical Information, Inc.)

Sexually transmitted diseases, Cases, Statistics, Clinical trials, Pelvic inflammatory disease, Cervicitis, Ofloxacin

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Predictors of success after embryo transfer: experience from a single provider

Article Abstract:

A successful pregnancy after in vitro fertilization is most likely if this is the first attempt and the embryos that are transferred are high-quality embryos. The difficulty of transfer, the initial diagnosis leading to infertility, and the type of catheter used did not significantly affect the outcome.

Fertilization in vitro, Human, Human fertilization in vitro, Embryo transplantation

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Hypertrophy of labia minora: experience with 163 reductions

Article Abstract:

Enlarged labia minora can be surgically corrected for cosmetic or health reasons. In a study of 163 women who requested such surgery, 93% were satisfied with the results.

Surgery, Vulva, Hypertrophy

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