Management of 168 neonates weighing more than 2000 g receiving intrapartum chemoprophylaxis for chorioamnionitis: evaluation of an early discharge strategy

Article Abstract:

Newborns needing a full seven-day course of antibiotics for suspected intrauterine infection may be able to be distinguished from infants for whom antibiotics can safely be discontinued at three days. All 168 newborns of mothers with presumed intrauterine infections born at a New York university hospital had body fluid cultures and blood cell counts. Antibiotic treatment was started shortly after birth. Antibiotics were discontinued at three days in the 137 infants (82%) with normal cultures and white cell counts, and no symptoms of infection. Antibiotics were continued for another four days in infants with symptoms of infection or positive laboratory tests. No infant in the short-term treatment group developed any signs or symptoms of infection after discontinuing antibiotics. This approach appears safe, and by reducing hospital stay, would save over $200 million annually if instituted nation wide.

Drug therapy, Infants (Newborn), Newborn infants, Hospitalization, Hospital utilization, Hospital stays, Chorioamnionitis

---

Analgesia and Sedation in Preterm Neonates Who Require Ventilatory Support

Article Abstract:

Low-dose morphine to control pain may reduce the risk of intraventricular hemorrhage and periventricular leukomalacia in premature newborn infants who require a ventilator. Pain and the physiological changes associated with it may increase the risk of neurological complications, such as bleeding in the brain, in newborn infants. Researchers assigned 77 preterm, ventilated infants to maintenance doses of morphine, midazolam, or dextrose. Neurological complications developed in 24% of infants receiving dextrose, which has no effect on pain; 32% of infants receiving midazolam for sedation, and 4% of infants receiving the narcotic morphine.

United States, Care and treatment, Evaluation, Complications and side effects, Pain, Infants (Premature), Premature infants, Brain, Brain hemorrhage, Morphine, Midazolam

---

Similar abstracts:

• Abstracts: The clinical significance of Pseudomonas aeruginosa isolation from stool of neonates. Resolution of middle ear effusion in newborns
• Abstracts: Mechanism of HIV persistence: implications for vaccines and therapy. part 2 An immunovirological study of central nervous system involvement during HIV-1 infection of chimpanzees
• Abstracts: Clinical research and drug development of antivirals in HIV: an industry perspective. part 2 Evaluating the cost of medications for ambulatory HIV-infected persons in association with landmark changes in antiretroviral therapy
• Abstracts: The role of pulse oximetry: its use as an indicator of severe respiratory disease in Peruvian children living at sea level
• Abstracts: The role of fibre in the treatment of secondary hyperlipidaemia in nephrotic patients. Effect of dietary fibre on weight correction after modified fasting

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.