The latent nuclear antigen of kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cells

Article Abstract:

Research indicates that an immunogenic latent nuclear antigen (LNA-1) of kaposi sarcoma-asociated herpesvirus (KSHV) is involved in maintaining KSHV episome and attaching it to chromatin during cell division. Data further show that LNA-1 mediates KSHV-induced oncogenesis via retinoblastoma protein-cell cycle transcription factor regulation pathway.

United Kingdom, Genetic aspects, Carcinogenesis, Human herpesvirus 8, Kaposi's sarcoma, Retinoblastoma

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Overexpression of deltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis

Article Abstract:

Results demonstrate that deltaFosB regulator of the activator protein-1 family of transcription factors, promotes bone mass and bone formation resulting in osteosclerosis. However, deltaFosB is shown to inhibit adipogenesis as shown in a transgenic mouse model.

United States, Germany, Metabolic regulation, Fat cells, Adipocytes

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Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1

Article Abstract:

Results demonstrate that Fra-1 protein of the activator protein-1 family of transcription factors influence bone mass and bone formation by increasing the number of osteoblasts and their differentiation as shown in a transgenic mouse model.

Austria, Switzerland, Models, Genetically modified mice

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