The management of chronic heart failure

Article Abstract:

Heart failure is caused by pathologic changes in the heart that affect its ability to pump blood. The resulting backup causes fluid to accumulate in various parts of the body. In addition, other organs are affected by the reduced blood supply. Drug therapy falls into two categories: drugs to relieve symptoms and drugs to slow progression of the disease. Symptom-relieving drugs include diuretics, vasodilators and digoxin. ACE inhibitors, hydralazine and isosorbide dinitrate can slow disease progression. Other promising drugs include beta-blockers and calcium channel blockers.

Health aspects, Vasodilators, Vasodilator agents, Diuretics

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Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both

Article Abstract:

A group of drugs called sartans may be as effective as ACE inhibitors for treating patients who have had a heart attack and also have heart failure, according to a study of approximately 15,000 patients. Combining both types of drug does not increase the benefit and may increase the risk of side effects. Sartans belong to a group of drugs called angiotensin-receptor blockers.

ACE inhibitors, Angiotensin converting enzyme inhibitors, Heart attack, Captopril

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A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure

Article Abstract:

The drug valsartan may be effective in treating heart failure but it should not be used if the patient is also taking an ACE inhibitor and a beta blocker. This was the conclusion of a study of 5,010 patients. Valsartan belongs to a group of drugs called angiotensin-receptor blockers.

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