The matrix degrades, neutrophils invade

Article Abstract:

A study focuses on an acetylated tripeptide derived from proteolytic cleavage of collagen and shows how this tripeptide serves in the lung as a chemoattractant for neutrophils and may also have a role in chronic obstructive pulmonary disease (COPD). COPD is primarily a systemic inflammatory disease of the lung, induced by cigarette smoke and is characterized by the presence of emphysema and chronic bronchitis.

Biological Product (except Diagnostic) Manufacturing, Drugs, Collagen, Causes of, Risk factors, Smoking

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Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease

Article Abstract:

Interleukin-8 (IL-8) has promoted bacterial killing by neutrophils through the chemokine receptor CXCR1 not CXCR2. The cleavage of CXCR1 and the identification of soluble CXCR1 fragments behaving like bioactive components have represented a new pathophysiologic mechanism in cystic fibrosis and other chronic lung diseases.

Cystic fibrosis

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Reversing systematic inflammatory response syndrome with chemokine receptor pepducins

Article Abstract:

A new therapeutic approach for the treatment of lethal sepsis using cell-penetrating lipopeptides termed pepducins that target either individual or multiple chemokine receptors is described. Interleukin-8(IL-8), a ligand for the CXCR1 and CXCR2 receptors, is the most potent endogenous proinflammatory chemokine in sepsis.

Peptides

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