The risk of the hemolytic-uremic syndrome after antibiotic treatment of Escherichia coli O157:H7 infections

Article Abstract:

Giving antibiotics to children with E. coli O157:H7 infection may increase their risk of hemolytic-uremic syndrome. Hemolytic-uremic syndrome is a kidney disease that also causes anemia. Among 71 children who had E. coli O157:H7 infection, 9 received antibiotics and 5 of these children (56%) developed hemolytic-uremic syndrome. Among the 62 children who did not receive antibiotics, only 5 (8%) developed hemolytic-uremic syndrome. This translates into a risk of hemolytic-uremic syndrome that is 17 times greater among children who receive antibiotics for E. coli O157:H7 infection.

Drug therapy

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E. coli, antibiotics, and the hemolytic-uremic syndrome

Article Abstract:

It may be necessary to avoid giving antibiotics to children infected with E. coli O157:H7. This strain of E. coli can cause intestinal disease as well as a kidney disease called hemolytic-uremic syndrome. A study published in 2000 shows that antibiotics can increase the risk of hemolytic-uremic syndrome in children infected with E. coli O157:H7. Bacterial cells that are damaged by antibiotics may release toxins. Antibodies against these toxins may help to prevent intestinal damage caused by the toxin.

Editorial

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Hemolytic-uremic syndrome in a six-year-old girl after a urinary tract infection with Shiga-toxin-producing Escherichia coli O103:H2

Article Abstract:

A case of hemolytic-uremic syndrome in Seattle caused by E. coli type O103:H2 indicates that this strain of the bacterium may have entered the US. A 6-year-old girl was admitted to a hospital with abdominal pain and vomiting. Tests revealed that she had hemolytic-uremic syndrome, a kidney disease usually associated with E. coli type O157:H7. A blood sample tested positive for E. coli, which turned out to be the O103:H2 type.

Case studies

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