The secretion of fluid by renal cysts from patients with autosomal dominant polycystic kidney disease

Article Abstract:

The cysts present in autosomal dominant polycystic kidney disease seem capable of secreting fluid. This secretion can be increased by as yet unidentified substances in the cyst fluid. Polycystic kidney disease is characterized by enlarged kidneys and the presence of cysts. The term autosomal dominant refers to the genetic mode of disease transmission. Eighteen cysts were removed from three kidneys taken from women with polycystic kidney disease. Tests were performed to determine secretion rates of both natural cyst fluid and a laboratory-made fluid inserted into the cysts. Cysts containing cyst fluid secreted more fluid than cysts containing artificial fluid. Cyst fluid also stimulated fluid secretion in canine and human kidney cells. Drug therapy may eventually provide a means of controlling the size of cysts.

Measurement, Secretion, Cysts

---

Polycystic kidney disease - there goes the neighborhood

Article Abstract:

The cysts in autosomal dominant polycystic kidney disease (ADPKD) may cause kidney failure by damaging normal tissue, rather than by simply crowding out the local tissue. Patients with ADPKD develop cysts in their kidney tubules and about 50% of them eventually experience kidney failure. The inherited gene mutation that leads to cyst growth in some forms of the disease has been identified. The cysts may damage other kidney tissue by triggering the release of cytokines and other chemicals that lead to the growth of scar tissue. A 1995 study showed that programmed cell death, known as apoptosis may be a characteristic of ADPKD. This study suggests that the genes responsible for ADPKD may also cause apoptosis. Through apoptosis, the cysts may cause destruction of kidney tissue.

Editorial

---

Volume progression in polycystic kidney disease

Article Abstract:

The cyst and kidney growth in a large cohort of patients with autosomal dominant polycystic kidney disease (ADPKD) are measured using statistical methods to determine the rate of disease progression. The results have shown that kidney enlargement resulting from the expansion of cysts in patients with ADPKD is continuous and quantifiable and is associated with the decline of renal function, whereas the higher rates of kidney enlargement are associated with a more rapid decrease in renal function.

United Kingdom, Methods, Diagnosis, Causes of, Diseases, Development and progression, Kidney diseases, Disease reporting

Similar abstracts:

• Abstracts: Studies on the mechanism of action of oral contraceptives with regard to fibrinolytic variables. Effects of monophasic low-dose oral contraceptives on fibrin formation and resolution in young women
• Abstracts: The safety of tricyclic antidepressants in cardiac patients: risk-benefit reconsidered. Relationship Between Depression and Other Medical Illnesses
• Abstracts: Baseline plasma fibrinolysis and its correlation with clinical manifestations in patients with Raynaud's phenomenon
• Abstracts: Prophylaxis against Pneumocystis carinii pneumonia among children with perinatally acquired human immunodeficiency virus infection in the United States

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.