There is an increase in expression of the cytotoxic T-lymphocyte antigen-2-alpha gene during pregnancy

Article Abstract:

The cell-killing T-lymphocyte antigen-2-alpha (CTLA-2-alpha) gene may be more active in the uterus during pregnancy. Researchers used a screen for various genes in DNA obtained from a pregnant and a nonpregnant mouse uterus and isolated several genetic clones related to the CTLA-2-alpha gene. The CTLA-2-alpha gene was active in the nonpregnant mouse uterus, but was much more active in the pregnant mouse uterus. Activity of the gene dropped after birth. Genetic activity of CTLA-2-alpha genes was also observed in placental RNA. CTLA-2-alpha genetic activity was not found in other fetal or maternal tissues sampled. Genetic information from CTLA-2-alpha genes is transferred to cells that fight infection and to activated T cells, both of which are present in the placenta and uterus.

Measurement, Cell-mediated cytotoxicity, Cell mediated cytotoxicity, Antigen receptors, T cell, T cell antigen receptors

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Cardiotoxic transplacental effect of idarubicin administered during the second trimester of pregnancy

Article Abstract:

The chemotherapy drug idarubicin should be used with extreme caution when treating pregnant women with cancer. Doctors report the case of a 23-year-old pregnant woman who received the drug during the second trimester for acute lymphocytic leukemia. The baby was delivered at 28 weeks and developed heart failure within three days of birth.

Causes of, Complications and side effects, Fetus, Chemotherapy, Heart failure, Idarubicin

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The effects of first-trimester diabetes control on the incidence of macrosomia

Article Abstract:

Elevated blood levels of glycosylated hemoglobin during the first trimester of pregnancy can predict which babies will be larger than normal. In a study of 120 women with diabetes, glycosylated hemoglobin levels were higher throughout pregnancy in the mothers who gave birth to larger than normal babies.

Statistical Data Included, Risk factors, Physiological aspects, Fetal macrosomia, Glycosylated hemoglobin

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