This day 50 years ago

Article Abstract:

On April 12, 1945, President Franklin D. Roosevelt died from a cerebral hemorrhage caused by years of untreated hypertension. Although the President was always said to be in excellent health, records of his cardiologist show that his blood pressure, which was 136/78 in 1935, continued to rise throughout his presidency. At the time of the Normandy invasion, his blood pressure was 226/118 and his EKG and chest X-ray revealed an enlarged heart. He also had protein in his urine, a sign that his kidneys were damaged by the pressure. In Roosevelt's time, physicians believed that high blood pressure was necessary to force the blood through atherosclerotic arteries, so they didn't always treat the disease. At his autopsy, the embalmers reported they had a hard time forcing the embalming fluid through his arteries. This indicates that he had severe atherosclerosis and this may have contributed to his high blood pressure.

Roosevelt, Franklin D., Malignant hypertension

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Underrepresentation of patients 65 years of age or older in cancer-treatment trials

Article Abstract:

Many clinical trials of cancer treatments do not include many elderly people even though cancer is primarily a disease of old age. Researchers analyzed the demographics of 164 cancer-treatment trials that included 16,396 patients. Women make up 43% of all cancer patients and 41% of the subjects in the trials were women. Similarly, blacks make up 10% of all cancer patients and 10% of the research subjects were black. In contrast, people 65 years old and older make up 63% of all cancer patients but only 25% of the research subjects were over 65.

Research, Cancer research, Demographic aspects, Clinical trials, Medical research, Cancer

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Redarkening of port-wine stains 10 years after pulsed-dye-laser treatment

Article Abstract:

A study used objective color measurements to perform a ten-year follow-up of a previously conducted prospective clinical study of the treatment of port-wine stains with a pulsed-dye-laser. Significant redarkening of the port-wine stains were observed at long-term follow-up, suggesting patients should be informed about the possibility of redarkening before beginning treatment.

Netherlands, Care and treatment, Usage, Port-wine stain, Dye lasers

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