Time-to-event analyses for long-term treatments--The APPROVe trial

Article Abstract:

Researchers working on the Adenomatous Polyp Prevention on Vioxx (APPROVe) trial collected data on adverse cardiovascular events, the assessment of which raises important issues about the analysis and interpretation of a time-to-event end point. These issues include the appropriate period of follow-up for safety outcomes after the discontinuation of treatment and the implications of the results of a trial examining long-term use about the safety of a drug if it were given for shorter periods.

Drug therapy, Long-term care of the sick, Long term care, Polyposis, Familial, Familial polyposis, Disease/Disorder overview

---

Trial registration at ClinicalTrials.gov between May and October 2005

Article Abstract:

ClinicalTrials.gov records are reviewed to determine patterns of completion of the 'Intervention Name' and 'Primary Outcome Measure' data fields for trials registered on May 20 and October 11, 2005 and for trials registered during the interval between these two dates, inclusively. It is concluded that during the summer of 2005, there were large increases in the number of clinical trial registrations.

Clinical trials, Records and correspondence

---

A controlled trial of homocysteine lowering and cognitive performance

Article Abstract:

A two-year clinical trial was conducted to test the hypothesis that in older people with elevated plasma homocysteine concentrations, decreasing homocysteine with B vitamins would result in better cognitive performance. However, findings do not support the hypothesis that homocysteine lowering with B vitamins improves cognitive performance.

Science & research, Aged, Elderly, Research, Physiological aspects, Cognition in children, Cognitive development, Homocysteine

Similar abstracts:

• Abstracts: Quality improvement guidelines for the treatment of acute pain and cancer pain. Effect of magnetic vs sham-magnetic insoles on plantar heel pain: a randomized controlled trial
• Abstracts: Quality-of-life analysis in the management of endometrial cancer. NovaSure impedance controlled system for endometrial ablation: Three-year follow-up on 107 patients
• Abstracts: Renal osteodystrophy. Long-term treatment of osteopetrosis with recombinant human interferon gamma
• Abstracts: Prehospital and hospital care. Academic medical centers' standards for clinical-trial agreements with industry
• Abstracts: Methotrexate for chronic diseases in adults. Treatment of Crohn's disease at the turn of the Century

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.