Tissue distribution of transplanted fetal liver cells in the human fetal recipient

Article Abstract:

Fetal liver cell transplants may be more likely of being engrafted in the host fetus's liver if they are injected into the heart rather than into the abdomen. The heart or abdomen of 10 normal fetuses scheduled for prostaglandin abortions were injected with radiolabeled fetal liver cells under ultrasonographic guidance. After abortion, the levels of fetal liver cells were compared in various fetal organs. Injections into the heart were associated with higher levels of fetal liver cells in the liver, spleen, thymus, kidney, lung, and placenta. Fetal liver cell transplants may treat fetal immune deficiencies.

Methods, Physiological aspects, Liver, Liver transplantation, Fetal tissue transplantation

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Fetal membranes act as a barrier for adenoviruses: gene transfer into exocoelomic cavity of rat fetuses does not affect cells in the fetus

Article Abstract:

A study was conducted to examine whether exocoelomic cavity between amniotic and chorionic membranes offered a minimally invasive route for gene transfer to the fetus during early pregnancy. It was concluded that in rodents, the exocoelomic cavity does not offer a route for gene transfer into the fetus.

Research and Development in the Physical, Engineering, and Life Sciences, Science & research, Research and Testing Services, Gynecological R&D, Research, Genetic aspects, Genetic transformation, Gynecological research

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