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Tobacco dependence and the nicotine patch: clinical guidelines for effective use

Article Abstract:

Nicotine patches may be an effective aide for individuals who are trying to quit smoking. Nicotine is the active ingredient in cigarettes and is responsible for the addictive nature of cigarette smoking. A survey of the medical literature found that approximately twice as many individuals using nicotine patches quit smoking by the end of treatment, compared with those using a patch containing a placebo (an inactive substance). Between 22% and 42% of those who used nicotine patches quit smoking for six months, compared with 2% to 28% of those who used a placebo patch. Treatment with the nicotine patch alleviates some of the withdrawal symptoms of nicotine addiction such as craving for cigarettes and depression. It does not prevent weight gain or increased appetite. Most individuals require treatment with the nicotine patch for six to eight weeks and should undergo some type of concurrent counseling.

Author: Fiore, Michael C., Jorenby, Douglas E., Baker, Timothy B., Kenford, Susan L.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1992
Drug therapy, Tobacco habit

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A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation

Article Abstract:

The antidepressant drug bupropion appears to be more effective than a nicotine patch for smokers who want to quit. Researchers randomly assigned 893 smokers to take bupropion, use a nicotine patch, use both bupropion and a nicotine patch, or take a placebo. Treatments lasted 8 to 9 weeks. One year later, 35% of those who used bupropion and a nicotine patch had quit smoking compared to 30% of those taking bupropion alone, 16% of those using a nicotine patch and 15% of those taking a placebo. Bupropion alone was almost as effective as bupropion plus a nicotine patch.

Author: Leischow, Scott J., Fiore, Michael C., Rennard, Stephen I., Smith, Stevens S., Daughton, David M., Jorenby, Douglas E., Baker, Timothy B., Muramoto, Myra L., Nides, Mitchell A., Johnston, J. Andrew, Hughes, Arlene R., Doan, Kimberli
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
Evaluation, Smoking cessation programs, Smoking cessation, Bupropion

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The Justice Department's case against the tobacco companies

Article Abstract:

A report is presented on the controversy plaguing the biggest civil case started in 1999 and brought by the Department of Justice against the tobacco industry. However, the corrective measures, which the lawsuit called for, are suddenly reduced by the Justice Department and whatever the obscure reasons, tobacco companies are allowed to flourish, while smokers continue to perish.

Author: Fiore, Michael C., Baker, Timothy B., Keller, Paula A.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
Legal issues & crime, Government regulation (cont), Government regulation, Management dynamics, Public affairs, TOBACCO PRODUCTS, Legal/Government Regulation, Tobacco farms, New England States, Social aspects, Management, Laws, regulations and rules, United States. Department of Justice, Smoking, Tobacco industry, Company business management, New England

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Subjects list: Health aspects, Transdermal medication, Nicotine, Transdermal drug delivery systems
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