Tracking the prevalence of transmitted antiretroviral drug- resistant HIV- 1: A decade experience

Article Abstract:

A total of 361 patients with acute or recent HIV-1 infection are prospectively studied over a decade (1995-2004) with respect to HIV-1 genotypes and longitudinal T-cell subsets and HIV-1 RNA levels to describe the changing pattern of transmitted drug-resistant HIV-1 in a well-defined cohort in New York City. Data provided have important implications for selection of empiric first- line regimens for treatment of acutely infected antiretroviral- naive individuals and reinforce the need or baseline resistance testing in acute and early HIV- 1 infection.

United States, Patient outcomes, HIV infection, Drug therapy, HIV infections, Drug resistance, Highly active antiretroviral therapy

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Bioengineering lactic acid bacteria to secrete the HIV-1 virucide cyanovirin

Article Abstract:

A study was conducted to describe the bioengineering of strains of lactic acid bacteria (LAB) to secrete the prototypic virucidal compound cyanovirin (CV-N) and demonstrate the anti-HIV-1 activity of secreted CV-N. The results suggest that recombinant LAB may serve as effective microbicidal compounds and deserve vivo testing in simian immunodeficiency virus models of mucosal virus transmission.

Cyanobacteria, Lactate dehydrogenase

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Willingness to use microbicides is affected by the importance of product characteristics, use parameters, and protective properties

Article Abstract:

The Important Microbicide Characteristics (IMC) instrument is evaluated psychometrically and its relationship to willingness to use microbicides is examined. The results show that, formulation and use characteristics and product functions affect willingness to use microbicides and it continues to be addressed in product development.

Usage, Health attitudes, Clinical report

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