Transdermal nicotine replacement in pregnancy: maternal pharmacokinetics and fetal effects

Article Abstract:

Nicotine skin patches may not produce negative effects in pregnant women who want an alternative to smoking and their fetuses. Researchers placed nicotine skin patches on six pregnant women who could not quit smoking otherwise. Nicotine levels in saliva increased with patch use, while cotinine levels in saliva stayed low during the eight hours that the patch was worn. Neither fetal nor maternal health appeared to be compromised with use of nicotine patches. Since this study was small, nicotine skin patches during pregnancy should still be considered a Pregnancy Category D medication.

Physiological aspects, Pregnant women, Transdermal medication, Transdermal drug delivery systems

---

Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth

Article Abstract:

The relationship of 5 nonsynonymous substitutions is examined in 4 folate metabolizing genes, including 5,10-methylenetetrahyrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR) and cytosolic serine hydroxymethyl-transferase (SHMT1), and their interaction with folate intake and risk of spontaneous preterm or small-for-gestational age (SGA) birth in a nested case-control study. The results have suggested the possibility of a direct or indirect role for the SHMT1 (1420)T variant in spontaneous preterm or SGA births.

Risk factors, Folic acid, Premature birth, Diet therapy

---

Similar abstracts:

• Abstracts: Corticotropin-releasing factor and its binding protein: maternal serum levels in term and preterm deliveries. Association between pregnancy-induced hypertension and asthma during pregnancy
• Abstracts: Antibiotic treatment in preterm premature rupture of membranes and neonatal morbidity: a metaanalysis
• Abstracts: Predicting respiratory distress syndrome using gestational age and fetal lung maturity by fluorescent polarization
• Abstracts: Circumferential pulmonary-vein ablation for chronic atrial fibrillation. A randomized study of prophylactic catheter ablation in asymptomatic patients with the Wolff-Parkinson-White syndrome
• Abstracts: Patterns of constipation in urogynecology: Clinical importance and pathophysiologic insights. The use of Visual Analog Scale in urogynecologic research: a psychometric evaluation

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.