Transforming growth factor beta2 in labial salivary glands in Sjogren's syndrome

Article Abstract:

Increased levels of transforming growth factor-beta2 (TGF-B2) in the salivary gland tissue of patients with Sjogren's syndrome (SS) indicates that TGF-B2 plays a role in the formation of fibrous scar tissue in these patients. TGF-B2 is a protein that stimulates tissue growth and wound healing. Researchers analyzed salivary gland tissue samples from 5 patients with primary SS, 5 patients with secondary SS, and 6 healthy volunteers. The levels of TGF-B2 were nearly 1.5 times higher in the patients with SS compared to the healthy volunteers. There was no significant difference in TGF-B2 levels between the patients with primary and secondary SS.

Transforming growth factors

---

Neutral endopeptidase (EC 3.4.24.11) in labial salivary glands in healthy controls and in patients with Sjogren's syndrome

Article Abstract:

The enzyme neutral endopeptidase (NEP) appears to be present only in nerve fibers but may prove to influence inflammatory activity in salivary glands of patients with Sjogren's syndrome. Endopeptidases accelerate the break down of proteins including nerve proteins. Researchers examined NEP distribution in salivary gland samples from 12 patients with Sjogren's syndrome and 8 healthy volunteers (control group). There was NEP in the ducts, nerve fibers, blood vessels, and nerve sacs surrounding the salivary glands but not within the gland. NEP activity was similar in the patient and control groups.

Proteases

---

Neuropeptides of the autonomic nervous system in Sjogren's syndrome

Article Abstract:

Autonomic nervous system activation, perhaps in response to stress, may have a role in the mouth dryness of Sjogren's syndrome (SS). SS is an autoimmune disorder that causes dry mouth, dry eyes, and inflammation of salivary and tear glands. Researchers compared neuropeptides in saliva, which indicate nerve cell activity, in 12 SS patients and 10 healthy volunteers. Salivary vasoactive intestinal peptide (VIP) and neuropeptide Y outputs were higher in SS patients, and stress was associated with high VIP concentration. Stress may decrease watery saliva output, raising VIP concentration.

Health aspects, Measurement, Stress (Physiology), Neuropeptide Y, Vasoactive intestinal peptides

Similar abstracts:

• Abstracts: Epidurals' benefit for back pain questioned. When shingles wanes but pain does not
• Abstracts: Is patient controlled analgesia worth the effect? More than a surgeon's handmaiden
• Abstracts: Mortality among children with Kawasaki disease in Japan. Serum concentrations of total bile acids in patients with acute Kawasaki syndrome
• Abstracts: Evaluating the longevity of restorative materials that seal the root canals of overdenture abutments. A clinical evaluation of a resin-modified glass ionomer restorative material
• Abstracts: Mitogenic effect of basic fibroblast growth factor and estradiol on cultured human myometrial and leiomyoma cells

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.