Increased thromboxane formation in diabetic pregnancy as a possible contributor to preeclampsia

Article Abstract:

Elevated levels of thromboxane may explain the increased risk of preeclampsia among pregnant women with diabetes. Preeclampsia is a metabolic disorder of late pregnancy characterized by high blood pressure. Thromboxane plays a role in constricting blood vessels. Urinary concentrations of thromboxane by-products, which reflect thromboxane formation, were measured in 24 pregnant women with diabetes and 20 healthy pregnant women. Levels of the thromboxane by-products were significantly higher in the women who were diabetic than in those who were not. The four diabetic women who developed preeclampsia had higher levels of one by-product than diabetic women without high blood pressure. These findings suggest that suppressing thromboxane formation in pregnant women with diabetes may lower their risk of preeclampsia.

Risk factors, Preeclampsia, Thromboxanes

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Maternal diabetes alters extracellular matrix protein levels in rat placentas

Article Abstract:

Changes in the level of extracellular matrix proteins may occur in the placentas of diabetic women. These proteins include structural proteins such as collagen. Researchers measured the levels of collagen, laminin and fibronectin in placentas taken form healthy pregnant rats and diabetic rats. Compared to healthy rats, placentas taken from diabetic rats had higher fibronectin levels and lower laminin levels. Structural abnormalities in the placenta could explain the worse outcome seen in infants of diabetic mothers.

Abnormalities, Placenta, Extracellular matrix

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