Interferon-gamma in the management of infectious diseases

Article Abstract:

Interferon-gamma may be effective in treating chronic granulomatous disease and certain bacterial and parasitic diseases. Interferon-gamma is one of many natural proteins produced by the body in reaction to infection. Patients with chronic granulomatous disease have an immune system deficiency allowing frequent infections to occur and fibrous tissue masses to form. Researchers reviewed current hypotheses on interferon-gamma's biological pathway of action and the diseases for which this natural protein may be effective. Immune response improved in thirty-four patients with chronic granulomatous disease treated with interferon-gamma. Given together with antibiotics, interferon-gamma has also been effective in treating two bacterial infections, leprosy and M. avium complex infections. Interferon-gamma treatment has also been effective in treating two parasitic infections, toxoplasmosis and leishmania.

Health aspects, Interferon gamma, Opportunistic infections, Toxoplasmosis, Leishmaniasis, Chronic granulomatous disease

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Effects of naloxone infusions in patients with the pruritus of cholestasis: a double-blind, randomized, controlled trial

Article Abstract:

Treatment with naloxone may help to relieve the itching symptoms of cholestasis. Cholestasis is an interruption in the flow of digestive fluids from or within the liver. Researchers compared the effect of naloxone with a placebo in 29 patients with itching symptoms associated with cholestasis. Patients randomly received either intravenous naloxone or placebo in 24-hour increments over a 4-day period. Patients rated their perception of itch on a scale from 0 to 10 every 4 waking hours. Researchers also electronically monitored the scratching movements of the patients. The patients reported a lower perception of itch with naloxone as compared to placebo. Scratching activity also declined with naloxone treatment as compared to placebo.

Evaluation, Cholestasis, Naloxone, Pruritus, Itching

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