Tumor angiogenesis formation of blood vessels de novo at germ cell tumors

Article Abstract:

Angiogenesis is the growth and development of blood vessels. It is an important feature of cancerous growths, since the rapidly growing neoplastic tissue must be supplied with nutrients and oxygen. There are two types of angiogenesis, an adult and an embryonic form. In the adult form, blood vessels arise as new branches from old vessels; this form is seen not only in most cancers, but also in chronic inflammatory diseases and other syndromes. The embryonic form of angiogenesis is the formation of blood vessels de novo, as undifferentiated precursor cells join together and organize to form a new blood vessel. In the course of organizing to form de novo blood vessels, embryonal cells form syncytia, the multinucleated giant cells that result from the fusion of many individual cells. It has previously been presumed that virtually all cancer-related angiogenesis is of the adult type. However, the systematic study of 346 biopsies and 56 autopsy specimens of testicular germ cells tumors revealed that both types of angiogenesis take place in these tumors. The formation of multinucleated cells and the de novo formation of blood vessels was observed in testicular germ cell tumors. However, it has not been possible to determine the source of the multinucleated cells nor the precise manner in which they appear. (Consumer Summary produced by Reliance Medical Information, Inc.)

Causes of, Germ cell tumors, Germinoma, Growth, Blood vessels, Neovascularization

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Malignant giant cell tumor associated with leiomyosarcoma of the uterus

Article Abstract:

Malignant giant cell tumor of soft parts resembles giant cell tumor of bone. It is a rare cancer and most often affects the legs. Only two cases of malignant giant cell tumor have been reported in the female reproductive tract. One case was a pure malignant giant cell tumor, and the other was a mixed giant cell tumor and leiomyosarcoma, or tumor of the smooth muscle. However, a case has now been documented in which both leiomyosarcoma and malignant giant cell tumor occurred in the uterus; the tumors were separate rather than mixed. The patient, a 56-year-old woman, was treated with hysterectomy, or removal of the uterus, but died 81 days later of metastasis, or tumor spread. Rapid, fatal metastasis is common among patients with malignant giant cell tumor. Histological examination revealed that the uterine tumors were anatomically and histologically distinct, and in all likelihood arose from different progenitor cells. This raises the question of whether the two tumors were coincidental, or whether the existence of one influenced the development of the other. The author reports that the large size of the slowly-growing leiomyosarcoma indicates that it preceded, and probably influenced, the rapidly-growing giant cell tumor. (Consumer Summary produced by Reliance Medical Information, Inc.)

Giant cell tumors, Leiomyosarcoma

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Melanin in a dentigerous cyst and associated adenomatoid odontogenic tumor

Article Abstract:

A dentigerous cyst is the most common form of follicular cyst, in which the tooth follicle of a removed tooth or an unerupted tooth forms a cyst. The dentigerous cyst is benign, though in very rare cases it may undergo malignant transformation. In an usual case involving an eight-year-old Nigerian boy, the dentigerous cyst was associated with an odontogenic, or tooth-forming, tumor. Both the cyst and the tumor contained melanocytes and melanin; this is believed to be the first such observation. Only fourteen previous cases of melanin in odontogenic lesions are to be found in the medical literature. Although the number of cases is small, it is tempting to speculate that the occurrence of melanin in odontogenic lesions is related to race. The boy in the present case was black, and only one of the previously reported cases involved a white patient. Nevertheless, even in Africa, where there is a high frequency of melanosis of the gums, large series of jaw lesions reported in the literature did not include a melanotic lesion. The odontogenic tumor as seen in the present case is generally benign. Although the patient did not return for follow-up, the surgery is believed to be curative. (Consumer Summary produced by Reliance Medical Information, Inc.)

Prognosis, Odontogenic cysts, Dentigerous cyst, Odontogenic tumors

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