Variability in meta-analytic results concerning the value of cholesterol reduction in coronary heart disease: a meta-meta-analysis

Article Abstract:

There is much support for the efficacy of cholesterol reduction, but meta-analyses of it have produced conflicting results. Researchers in this study assessed the variability of meta-analyses by evaluating the cardiovascular value of cholesterol reduction as they attempted to explain the variability. They identified meta-analyses by electronic search and citation tracking. They reviewed 20 meta-analyses, 15 of which concluded that cholesterol reduction is beneficial. Summery odds ratios failed to support the value of cholesterol reduction because they were heterogeneous. However, odds ratios for cardiovascular mortality and nonfatal cardiovascular disease were homogenous and supported the value of cholesterol reduction.

Cardiovascular diseases, Hypercholesterolemia

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Effect of change in sodium excretion on change in blood pressure corrected for measurement error

Article Abstract:

Variability from person to person in both blood pressure (BP) and sodium excretion cuts down on associations and leads to underestimates of the dose-response relation. Statistical correction techniques from the Trials of Hypertension Prevention (TOHP), Phase I, 1987-90 have been applied to data. Results indicate that possibly the true effect of sodium change on BP change in those with normal BP over 18 months estimated at too low a level by more than half in uncorrected data.

Standards, Hypertension, Causes of, Physiological aspects, Potassium (Chemical element), Sodium, Sodium (Chemical element), Epidemiological research, Cross sectional studies, Potassium, Salt (Food), Medical statistics, Sodium (Nutrient), Salt in the body

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Comments on a meta-analysis of the relation between dietary calcium intake and blood pressure

Article Abstract:

The American Journal of Epidemiology in 1995 published the results of a study on the issue of meta-analysis. However, the results were incorrectly extracted and converted, which led to an understatement of the calcium-blood pressure relation. Upon repeating the meta-analysis, researchers found an unadjusted regression slope between dietary calcium and systolic blood pressure. These slopes were larger than those in the original analysis.

Calcium (Nutrient), Calcium, Dietary

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