Nuclear receptors and chemical carcinogenesis

Article Abstract:

Several non-genotoxic carcinogens such as peroxisome proliferators and dioxins promote alterations in gene expression via the activation of intracellular receptor signal transduction pathways. These carcinogens imitate the function of receptor-specific natural ligands which facilitate cellular growth and eventually cause tumor formation. Experiments further indicate that hyperplasia is involved in the mitogenicity of the carcinogens. In addition, these carcinogens primarily interact with receptors included in the superfamily of steroid hormone receptors.

Physiological aspects, Somatotropin, Carcinogenesis, Dioxin, Dioxins, Carcinogens, Steroid hormones, Steroid receptors, Genetic toxicology, Transduction, Transduction (Genetics), Somatotropin receptors

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The mysteries of sigma receptors: new family members reveal a role in cholesterol synthesis

Article Abstract:

A study was conducted on the role of sigma receptors in drug development. Since sterols are vital to cell division, it is argued that sterol biosynthesis inhibitors stem cell growth. Furthermore, results indicate that the inhibition of post-squalene sterol biosynthesis in the brain may, in the long-term, be used to develop therapeutics for psychosis and other mental disorders.

Cellular signal transduction, Cell receptors

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