The angiotensin AT2 receptor: searching for signal-transduction pathways and physiological function

Article Abstract:

A second subtype of angiotensin (AT) receptor, dubbed as AT2, has been identified through analysis of peptidic and non-peptidic ligands in the signal transduction pathway. It is expressed at high levels in the fetus and selectively expressed to the adrenals, ovary, heart and specialized nuclei in the brain in adults. Initial studies suggested that AT2 do not possess the properties that characterize G protein-coupled receptors and thus, may belong to an unknown class of receptors. However, expression cloning of cDNA indicated that AT2 are structurally-related to G protein-coupled receptors.

Hypertension, G proteins

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Functional expression of receptors in microorganisms

Article Abstract:

Microbial cells can be used as alternatives to functionally express mammalian receptors for ligand screening. The bacteria, E. coli and the yeast, S. cervisiae are capable of expressing G-protein-coupled receptors such as three beta-adrenoceptor subtypes, 5-HT and the M1 muscarinic acetylcholine receptor. Soluble steroid receptors have been demonstrated to functionally interact with bacterial and yeast DNA while retaining their steroid-binding and hormone-responsive transcription properties.

Research, Cell receptors, Microbial genetics

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Angiotensin receptor subtypes in the brain

Article Abstract:

Studies have shown that AT1 and AT2 are two differing angiotensin receptor subtypes present in the brain, with differing functions and signal transducting mechanisms. The AT1 receptor regulates most of the known central functions of angiotensin 11, such as maintaining the blood pressure and electrolyte and water balance, while little is known about the function of the AT2 receptor.

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