Background genes: out of sight, but not out of brain...

Article Abstract:

Advancements in genetic manipulations have benefited the field of central nervous system injury, particularly in the area of neuronal alteration. A paper by P Schauwecker and O Steward, however, has highlighted the potential importance of genetic background in the interpretation of the findings of gene-targeting studies. These scientists have found out that certain strains of mice injected with kainate fail to develop selected excitotoxic hippocampal cell death in spite of developing pronounced seizures.

Analysis, Genetic aspects, Mice, Mice (Rodents), Genetic engineering, Nervous system, Nerve degeneration, Convulsions

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Calcium: still center-stage in hypoxic-ischemic neuronal death

Article Abstract:

The theory of the relation of Ca-super2+ excess entry, resulting in neuronal-cell Ca-super2+ overload, to hypoxic-ischemic neuronal death is heuristic and can be refined. Research on Ca-super2+ entry reveals that it is caused by glutamate toxicity in cases of hypoxic-ischemic brain damage and NMDA-induced toxicity is caused in part by neuronal nitric oxide synthase, which is activated by Ca-super2+-calmodulin.

Cerebral ischemia, Cerebral anoxia

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Reflections on Ca(2+)-channel diversity, 1988-1994

Article Abstract:

Ca-super2+-channels research has developed considerably since 1988. Molecular cloning has allowed scientists to delve into the mysteries of voltage-gated Ca-super2+ channels, of which less than 10 have been identified. In addition, molecular cloning enables scientists to examine subunit structure and key channel characteristics, which include selectivity, permeation, and activation and nonactivation gating.

Usage, Calcium channels, Cloning

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