Crossing the hydrophobic barrier: insertion of membrane proteins

Article Abstract:

Research on alpha hemolysin has revealed the mechanism through which proteins insert spontaneously within or across the hydrophobic barrier. The protein penetrates a lipid barrier though spontaneously forming an oligomeric beta barrel.

Biological transport, Hemolysis and hemolysins, Hemolysis, Lipid membranes, Bilayer lipid membranes

---

Defects in the barrier

Article Abstract:

Defects in the genes that control a wide variety of the processes involved in keratinization produce four types of clinically similar skin disorders called ichthyoses. The physiology of these skin barrier disorders is discussed.

Genetic aspects, Keratosis, Ichthyosis

---

Discovering high-affinity ligands for proteins: drug design

Article Abstract:

Methods of identifying highly bondable molecules, for new drug synthesis, are examined. The goal is to find linked compounds with submicromolar affininties, using combinational chemistry and parallel synthesis.

Usage, Drugs, Nuclear magnetic resonance spectroscopy, Ligands (Biochemistry)

Similar abstracts:

• Abstracts: Role of microstructure in the thermomechanical behavior of SMA composites. The role of rate effects and of thermomechanical coupling in shear localization
• Abstracts: And then there were three. Origins of fullerenes in rocks. Fullerene formation and annealing
• Abstracts: Probing the geodynamo. Heike Kamerlingh Onnes's discovery of superconductivity. Probing high-temperature superconductivity
• Abstracts: Pumping Iron Through Celt Membranes. Nuclear Fusion of Signaling Pathways. Signaling across membranes: a one and a two and a...
• Abstracts: PAS, present and future: clues to the origins of circadian clocks. The ever-present packaging challenge

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.