Deconstructing Vancomycin
Article Abstract:
Vancomycin is a powerful antibiotic that has been a last resort of methicillin-resistant S. aureas and other multi-drug-resistant Gram-positive bacteria. However, reports that some patients are not responding to vancomycin raise fears of an antibiotic-resistant superbug. Research into the structure of vancomycin may help develop sugar-based fragments that are adept at killing vancomycin-sensitive and vancomycin-resistant pathogenic bacteria.
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1999
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Vancomycin resistance: decoding the molecular logic
Article Abstract:
Researchers have identified nine genes that are responsible for resistance to the antibiotic vancomycin in pathogenic enterococci. The finding could lead to the development of strategies to prevent new resistant microbes.
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1993
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Non-heme Fe (IV)-Oxo intermediates
Article Abstract:
The detection and characterization of high-valent non-heme Fe (IV)-oxo enzyme intermediates of various alpha KG-dependent oxygenases that catalyze either hydroxylation or halogentaion of their substrates is presented.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2007
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