Free Copper Ions in the Cell?

Article Abstract:

Transitional metal ions, such as copper and iron, are essential for life, but must be regulated by cells to ensure the body maintains the necessary biological level while avoiding toxic levels. One such cell chaperone, yCCS, is responsible for regulating and delivering copper ions to copper-zinc superoxide dismutase (SOD1). SOD1 is mutated in people with an inherited form of Lou Gehrig's disease. This study looks at the intricacies of the relationship between yCCS and SOD1.

Research, Transition metals, Copper in the body, Copper (Nutrient), Copper ions, Amyotrophic lateral sclerosis

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Metal based turn-on fluorescent probes for sensing nitric oxide

Article Abstract:

The reactions between nitric oxide and transition metal complexes to devise metal-based fluorescent sensors that satisfy the aforementioned criteria are discussed. The evolution of transition-metal-based strategies for nitric oxide sensing as well as detailed mechanistic studies of the underlying chemistry are described.

Industrial Gas Manufacturing, Industrial gases, Nitric Oxide, Fluorescence, Optical properties, Chemical properties, Diamines

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Solvent-mediated proton transfer in catalysis by carbonic anhydrase

Article Abstract:

The high-resolution X-ray crystal structure of human carbonic anhydrase II (HCA II) which provide details of an ordered solvent structure extending between the proton donor and acceptor of catalysis, the conformations of the side chain of His64, and the nature of the zinc-bound solvent molecule is presented.

Protons, Catalysis, Carbonic anhydrase inhibitors

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