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How cancer arises

Article Abstract:

Mutations in proto-oncogenes and tumor suppressor genes have a major role in the development of cancer. The mutations cause proto-oncogenes to promote excessive cell multiplication and tumor suppressor genes to become inactivated.

Author: Weinberg, Robert A.
Publisher: Scientific American, Inc.
Publication Name: Scientific American
Subject: Science and technology
ISSN: 0036-8733
Year: 1996
Health aspects, Mutation (Biology), Mutation, Proto-oncogenes

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New molecular targets for cancer therapy

Article Abstract:

Researchers are studying how molecular defects cause normal cells to become cancerous. Most tumors have mutations in either oncogenes, tumor suppressor genes or genes that control DNA replication and repair.

Author: McCormick, Frank, Oliff, Allen, Gibbs, Jackson B.
Publisher: Scientific American, Inc.
Publication Name: Scientific American
Subject: Science and technology
ISSN: 0036-8733
Year: 1996
Research, Usage, Adenoviruses, Oncogenes, Biomolecules

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How drug resistance arises

Article Abstract:

The prolific rate of reproduction of HIV viral particles and the random mutations that occur in the replication process ensures that complete HIV viral control is still a long way off.

Author: Richman, Douglas D.
Publisher: Scientific American, Inc.
Publication Name: Scientific American
Subject: Science and technology
ISSN: 0036-8733
Year: 1998
Analysis, HIV (Viruses), HIV, Viruses, Drug resistance

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Subjects list: Physiological aspects, Genetic aspects, Cancer, Cancer genetics, Tumor suppressor genes, Tumour suppressor genes
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