Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice

Article Abstract:

Hypertriglyceridemia, or an excess in the blood of particular fats called triglycerides, is quite common, and is associated with premature coronary heart disease. Some people have hypertriglyceridemia (HTG) as a result of an inherited trait; for others it is a result of obesity, diabetes, alcoholism, or other factors. To investigate the role of specific genes in the development of HTG, investigators examined the effect of human genes transfected into mice. In particular, the effect of the gene for apo CIII was studied. Apo CIII is a protein that is found in chylomicrons, the tiny fat globules which carry digested fat from the intestine into the circulation. Apo CIII is also a major constituent of very low-density lipoprotein in the blood. It was found that the transfection of the apo CIII gene into mice resulted in a syndrome of hypertriglyceridemia. The triglyceride fats measured in the blood of the individual mice correlated almost exactly with the level of human apo CIII in the same animal. These results suggest that the overexpression of the apo CIII gene can lead directly to HTG. Factors that contribute to the abnormal regulation of this gene in humans may also contribute to the syndrome of hypertriglyceridemia. (Consumer Summary produced by Reliance Medical Information, Inc.)

Models, Physiological aspects, Apolipoproteins, Hyperlipidemia, Hyperlipoproteinemia

---

Could transgenic supercrops one day breed superweeds?

Article Abstract:

Some ecologists are worried that genetically engineered crops could help breed stronger weeds by spreading their genes engineered for disease resistance or other advantages. The problem could be elevated in developing countries, where crops may be introduced near closely related wild plants.

Environmental aspects, Agricultural biotechnology, Genetically modified plants, Weeds

---

Polyalanine expansion in synpolydactyly might result from unequal crossing-over of HOXD13

Article Abstract:

A genetic study found that polyalanine repeat expansion in the protein HOXD13 cause the webbing and digit duplication called synpolydactyly. Another study suggests that unequal crossing-over is the mechanism for the mutations.

Research, Mutation (Biology), Mutation, Crossing over (Genetics)

Similar abstracts:

• Abstracts: Brooklyn Bridge deck replaced at night. Coronado bridge undergoes second seismic upgrade
• Abstracts: Investigation on active isolation of machine foundations by open trenches. Large model spread footing load tests on geosynthetic reinforced soil foundations
• Abstracts: Numerical modeling of resistance brazing process behavior in joining electrical contact materials. Thermal phase transformation and residual stress estimation of multi-layer materials for cylindrical or flat shape
• Abstracts: Beating a sudden killer. How the brain creates the mind
• Abstracts: Creating a winning culture. Creating support for a change in strategy. Value people, the missing link in creating high performance organizations

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.