Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration

Article Abstract:

Notch signaling mediates many different intercellular communication events that are essential for determining the fates of neural and nonneural cells during the development and in the adult. The notch receptor is experimentally shown to act in a core pathway as a membrane-bound transcription factor that is released to the nucleus by a two-step cleavage mechanism called regulated intramembrane proteolysis (RIP).

Genetic transcription, Transcription (Genetics), Amyloid beta-protein, Proteolysis, Neurodegenerative diseases

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The nogo signaling pathway for regeneration block

Article Abstract:

The functional properties and signaling mechanism of myelin associated inhibitors of axon regeneration with an emphasis on a comparison of the mechanisms involved in developmental axon guidance is focused. The findings suggest the presence of inhibitory influences in the adult CNS environment.

Glycoproteins, Myelin proteins, Nerve degeneration

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