PH domains - a universal membrane adapter

Article Abstract:

Recent cytochemical research on such molecules as proto-oncogenic serine threonine kinase (Akt) and phosphophoinositide 3-kinase (PI3-kinase) indicates the important role played by PH domains in carrying signals across cell membranes. Several developments concerning PH domains are described.

Membrane proteins, Cytochemistry, Proto-oncogenes, Phosphoinositides, Phosphatidylinositols

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Akt signaling: linking membrane events to life and death decisions

Article Abstract:

Recent studies show that the serine/threonine protein kinase Akt, or protein kinase B, may be involved in growth factor maintenance of cell survival. New information on the signal propagation mechanism from growth factor receptor tyrosine kinases (RTKs) to Akt is analyzed.

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Digging into caveolae

Article Abstract:

A new purification method for caveolae, which uses the biophysical properties of lipids, demonstrates the strategy cells use to maintain caveolae. Caveolae and detergent-insoluble glycosphingolipid-enriched complexes are compared.

Plasma membranes, Cell organelles, Organelles

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