Synthesis molecules as antibody replacements
Article Abstract:
The study reviews efforts to overcome limitations of rarely exhibiting the high affinity and specificity typical of good antibody facile, high-throughput methodology for the isolation of synthetic protein ligands with antibody-like binding characteristics. Further the data suggesting that bivalent ligands may provide the most effective general strategy to access the synthetic compounds are presented.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2004
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Structure-function relationships of EcDOS, a Heme-Regulated Phosphodiesterase from Escherichia coli
Article Abstract:
Recent studies have revealed a new class of heme enzymes, the heme-based sensors, which are able to turn on or off cellular signal transduction pathways in response to environmental changes, one of these enzymes is the heme-regulated phosphodiesterase from Escherichia coli (EcDOS). Findings on the structure-function relationships of EcDOS is reviewed.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2006
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Lipid-protein interactions revealed by two-photon microscopy and fluorescence correlation spectroscopy
Article Abstract:
The use of two-photon excitation microscopy and fluorescence correlation spectroscopy is reviewed in the study of lipid-protein interactions. These new methodologies and techniques are discussed and the examples of different complexity from qualitative to quantitative from simple model systems to studies in living cells are presented.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2005
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