Understanding nucleic acids using synthetic chemistry

Article Abstract:

The work done in the laboratories that use synthetic, physical organic, and biological chemistry to understand the roles played by the nucleobases, sugars, and phosphates of DNA in the molecular recognition process central to genetics is described. The use of ribose reflects prebiotic processes in the presence of borate-containing minerals, which stabilize ribose formed from simple organic precursors.

Chemical structure, Chemical properties

---

Conformationally constrained PNA analogues: Structural evolution toward DNA/RNA binding selectivity

Article Abstract:

Structural preorganization of the backbone to hybridization-competent conformations to impart binding selectivity is presented. This strategy has allowed to design locked PNAs to achieve specific hybridization with DNA or RNA with aims to increase the binding strength without losing the binding specificity.

Analysis, Nucleic acid hybridization

---

Structural basis of single-stranded RNA recognition

Article Abstract:

RNA is a mediator of genetic information and plays essential roles in splicing and translation. The important principles and distinct features of single-stranded RNA recognition by conserved RNA binding domains are discussed.

RNA, Structure

Similar abstracts:

• Abstracts: Cleaning the air: using scientific information to regulate reformulated fuels. Will ethanol-blended gasoline affect groundwater quality?
• Abstracts: Adaptive strategies in the Indian pharmaceutical industry. Development strategies and prospects for Taiwan's R&D service industry
• Abstracts: Development of a coordination chemistry-based approach for functional supramolecular structures. Supramolecular metal-organic coordination networks based on quinonoid pie-complexes

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.