Aging and the pharmacokinetics and metabolism of metoprolol enantiomers in the rat
Article Abstract:
The effect of age on the stereoselective pharmacokinetics of metoprolol in the rat after intravenous and oral administration was studied. Results showed that intravenous adinstration did not result in different plasma concentrations and pharmacokinetic parameters of the R and S enatiomers. Half-life was prolonged and volume of distribution decreased from three to 12 months and increased from12 to 24 months. Oral administration was lower for R metropolol. Maximum plasmaconcentration and the area under the plasma concentration-time curve increased for both enantiomers with aging.
Publication Name: Journals of Gerontology
Subject: Seniors
ISSN: 0022-1422
Year: 1993
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Aging as a modulator of respiratory sinus arrhythmia
Article Abstract:
The relationship between aging, sympathovagal balance and arteriolar compliance (AC) is assessed by a cross-sectional investigation measuring respiratory sinus arrhythmia (RSA) and finger pletysmography under controlled conditions in 70 normotensive male volunteers. RSA and AC decreased with age with significant differences between six decade groups. Thus, there is an age-related loss of vagal-cardiac activity that may be partly attributed to arteriolar compliance.
Publication Name: Journals of Gerontology
Subject: Seniors
ISSN: 0022-1422
Year: 1993
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