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Post-translational control

Article Abstract:

There are various changes in post-translational control in senescent cells which include modifications in proteolysis, phosphorylation and dephosphorylation modifications. Changes in proteolysis processing affects the rate of protein production. Others implicatethe decline of protein degradation pathways with age. Moreover, specific phosphorylation and dephosphorylation processes affecting cell cycle regulationmay also be involved in senescence.

Author: Wang, Eugenia
Publisher: Gerontological Society of America
Publication Name: Journals of Gerontology
Subject: Seniors
ISSN: 0022-1422
Year: 1992

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Regulatory pathways and differentiation

Article Abstract:

Different cell types exhibit different alterations in cellular functions during senescence and terminal differentiation. Human melanocytes show growth arrest during senescence and terminal differentiation but increase in melanin is only found in the terminal diferentiation. Endothelial cells, on the other hand, do not undergo terminal differentiation but arrest in G0 phase of the cell cycle occurs.

Author: Campisi, Judith
Publisher: Gerontological Society of America
Publication Name: Journals of Gerontology
Subject: Seniors
ISSN: 0022-1422
Year: 1992
Cell differentiation

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Subjects list: Aging, Genetic aspects
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