Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease

Article Abstract:

It is suggested that Alzheimer's disease (AD) may involve a long preclinical period of neuropathological changes before the occurrence of full dementia. A newly discovered genetic risk factor for AD, the epsilon4 allele of the apolipoprotein E gene (ApoE-epsilon4), is an important risk factor in both late-onset familial and sporadic cases of AD. The relationship between ApoE genotype and cognitive performance was examined by included all nondemented participants at a baseline examination and by analysis of data on a subset of nondemented participants, excluding those who became demented or had no follow up evaluations. More ApoE-epsilon4 participants developed probable AD compared with non-epsilon4 participants.

Apolipoproteins

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Learning and retention in preclinical and early Alzheimer's disease

Article Abstract:

A long-term survey of 537 Alzheimer disease patients was undertaken to find out whether memory impairment in early or preclinical stage of the disease was a result of learning or retention abilities or a mixture of both. Results show that the learning and retention variables operated independently, with some participants exhibiting either but not both at the same time. Learning deficit appear to precede retention deficit in many participants.

Psychological aspects, Aged, Elderly, Memory, Learning ability

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Contextual constraint facilitates semantic decisions about object pictures by Alzheimer patients

Article Abstract:

Alzheimer patients were found to retain their ability to distinguish between semantic features in speech. Older adults with and without Alzheimer were asked to decide whether substituted for a word at the end of a sentence was an appropriate semantic ending for the sentence. Both groups of patients performed similarly in the test, and experienced difficulties as the semantic constraints on the sentences were made more difficult.

Cognition disorders in old age, Geriatric cognitive disorders

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