Relationship between glucose tolerance and glucose-stimulated insulin response in 65-year-olds

Article Abstract:

Insulin response of healthy 65-year-olds with varying glucose tolerances was compared to that of a 24-year-old control group with normal glucose tolerance. Insulin response to a three-hour hyperglycemic clamp was not sustained in older subjects with minimally decreased glucose tolerance. Subjects with severely impaired glucose intolerance showed a blunting of early insulin response and decreased response during the third hour. Since some older individuals showed no evidence of reduced glucose tolerance, it cannot be concluded that glucose tolerance necessarily decreases with age.

Glucose tolerance tests, Glucose tolerance test, Glucose

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Endurance exercise training reduces glucose-stimulated insulin levels in 60-to 70-year-old men and women

Article Abstract:

The effect of a 9-month vigorous endurance exercise training on the glucose-stimulated insulin response and glucose disposal rate in 60- to 70-yearolds was assessed. Results showed that plasma insulin levels declined after theexercise program. Moreover, insulin action improved at levels usually found in young subjects. Thus, regular exercise can be effective in reducing hyperinsulinemia while improving insulin action.

Glucose metabolism, Exercise for the aged

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Exercise increases average longevity of female rats despite increased food intake and no growth retardation

Article Abstract:

Female rats were tested to determine if exercise or wheel running can increase longevity despite a large increase in energy intake. Results showed that runners increased their weight faster than sedentary rats. Average longevity also increased although maximum life span did not increase. Thus, exercise improves average longevity independent of decreased availability of energy for cell proliferation and growth.

Health aspects, Exercise physiology, Longevity, Rats

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