The steady-state levels of type I collagen mRNA are reduced in senescent fibroblasts

Article Abstract:

Collagen is a protein found in various tissues in the body, and in the skin it is responsible for its elasticity. In aging skin, the collagen content progressively decreases. It is thought that one reason for this decrease is the slowed production of procollagen (a precursor of collagen) by the senescent (aging) fibroblast cells. This could happen if there was a decrease in the transcription of collagen genes - a process in which the genetic code is transmitted through messenger RNA (mRNA) to form new cells. To assess the likelihood of this hypothesis and the mechanism by which fibroblasts decrease their production of procollagen, levels of mRNA were measured in actively proliferating and senescent fibroblast cells in the laboratory. It was found that the levels in senescent fibroblasts were significantly lower than those in active fibroblasts. This suggests that one explanation for the decrease in collagen production in aging skin is a decrease in the synthesis of collagen mRNAs in older fibroblasts. (Consumer Summary produced by Reliance Medical Information, Inc.)

Physiological aspects, Collagen, Fibroblasts, Skin Aging

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Growth factors and signal transduction

Article Abstract:

Certain steps in the stimulation of various growth factors may be impaired in senescence. It is known that peptide growth factor cell surface receptors are not decreased but there are some changes in phosphorylation reactions as well as in some binding proteins. Furthermore, the G-S1 boundary is blocked during senescence which maybe regulated by second messengers. Some research also show that signal transduction differs between young and old cells.

Research, Growth factors, Cellular signal transduction

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Control of DNA synthesis in senescent cells

Article Abstract:

Senescent cells can not proliferate in the presence of growth factors. This is probably due to the presence of an inhibitor of DNA synthesis which may either directly inhibit theproduction of DNA or is a secondary effect of another cause of cellular senescence. The genetic restriction occurs somewhere about the G-S1 boundary ofthe cell cycle. Definite proof can only be acquired by isolating and characterizing the putative DNA synthesis inhibitors.

DNA, Genetic regulation, Genetic transcription, Transcription (Genetics)

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