Role of 5HT(sub 1A) receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man

Article Abstract:

Experiments were conducted to study the effect of 5HT(sub 1A) receptor agonist ipsapirone on aggressive tendencies among rats. Two groups of male Norwegian rats, one wild and one domesticated, were injected with ipsapirone and subjected to different behavioral tests. The results indicated that ipsapirone decreased shock-caused aggression in both the groups. Phobia of novel objects and defensive response was decreased among the wild rats while both groups exhibited normal predatory aggression. The increased level of 5HT(sub 1A) in the domesticated rats' hypothalamus, further suggests that these receptors play an important role in regulation of defensive behavior.

Rattus norvegicus, Norway rat, Serotonin, Serotonin receptors

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Selection for reduced aggressiveness towards man and dopaminergic activity in Norway rats

Article Abstract:

The neural dopaminergic activity of domesticated Norway rats was studied. The study showed the effect of dopamine levels and its metabolism in the brain's dopaminergic systems, the binding patterns of dopamine receptors, and dopamine-induced behavior, such as locomotion and irritable aggression in rats bred for nonpresence of agonistic reaction. The study proved that domestication is related to a lessening of dopamine levels in the striatum, altered metabolism of dopamine in the mesolimbic system, and a change in sensitivity and density of D-2 receptors.

Measurement, Dopamine, Domestication

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Regional studies of brain biogenic amines in castrated muricidal and non-muricidal Wistar rats

Article Abstract:

A comparative study of the brain biogenic amines in castrated muricidal and castrated non-muricidal Wistar rats is made. Castrated muricidal rats, which are more violent than castrated non-muricidal rats, have shown higher 5-HT levels in five areas of the brain considered to be involved in aggressive behavior. These five areas are the raphe, amygdala, olfactory tubercles, olfactory bulbs and striatum.

Physiological aspects, Castration

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