A DNA-based method for rationally assembling nanoparticles into macroscopic materials

Article Abstract:

Specific DNA interactions are used to assemble colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates. Non-complementary DNA oligonucleotides capped with thiol groups are attached to the surfaces of two batches of 13 nm gold particles. These oligonucleotides bind to gold. When oligonucleotide duplex with sticky ends, complementary to the two grafted sequences, is added to this solution, the nanoparticles self-assemble into aggragates. This process can be reversed through thermal denaturation.

Analysis, Nucleic acid probes, Gold, Colloids, Macromolecules

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Semiconductors meet biology

Article Abstract:

It has been possible to screen a combinatorial library made up of millions of peptides with unknown binding properties to find those peptides with selective affinities for a number of semiconductor surfaces. Peptide sequences capable of distinguishing between different semiconductors were selected.

Peptides, Binding sites (Biochemistry), Active sites (Biochemistry), Peptide synthesis

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Boning up on biology

Article Abstract:

Issues concerning nanotechnology and the fabrication of synthetic biological materials is presented. In particular the response of organisms to introduced materials at the nanoscale level with particular reference to bone structures is examined.

Nanotechnology, Bone cells, Artificial organs

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