A blueprint of 'bad air'

Article Abstract:

Bowman and colleagues have revealed the entire sequence of the Plasmodium falciparum chromosome 3, giving 7% of the total P. falciparum genome. The genome is complex but there is a certain organization where clusters of genes encoding proteins produced at similar stages in the life cycle appear to be grouped in certain chromosomes. The genome sequence should be used to identify new drug targets, to help in developing vaccines and to understand the pathogenesis of malaria.

Malaria, Plasmodium falciparum

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Functional links between proteins

Article Abstract:

Marcotte and colleagues and Enright and colleagues have developed computational methods associating proteins through properties other than their similar amino-acid sequences. They have compared phylogenetic profiles and expression patterns and as there is no reliance on direct sequence similarity, the method will find many applications in genomics.

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