A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
Article Abstract:
It is possible that N-CoR, a protein of relative molecular mass 270,000 which binds to the ligand-binding area of thyroid-hormone and retinoic-acid receptors, mediates ligand-independent transcriptional repression. Researchers have identified a complex which contains this protein, the histone deacetylase mRPD3 and the Mad presumptive co-repressor mSin3. It has been found that both N-CoR and mSin3 are vital elements of a co-repressor complex which is needed for transcriptional repression in at least two classes of DNA-binding proteins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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A SUMOylation-dependent pathway mediates transrepression of inflammatory genes by PPAR-gamma
Article Abstract:
The identification of a molecular pathway by which peroxisome proliferator-activated receptor-gamma (PPAR-gamma) represses the transcriptional activation of inflammatory response gene in mouse macrophages is reported. The initial step of this pathway involves ligand-dependent SUMOylation of the PPAR-gamma ligand-binding domain, which targets PPAR-gamma to nuclear receptor corepressor (NCoR)-histone deacetylase-3 (HDAC3) complexes on inflammatory gene promoters.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
Article Abstract:
The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) was found to be strongly upregulated in activated macrophages. It inhibited the expression of the inducible nitric oxide synthase, gelatinase B and scavenger receptor A genes. The activities of transcription factors AP-1, STAT and NF-kB were antagonized, suggesting that PPAR-gamma is involved in inflammatory response regulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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