A family of hyperpolarization-activated mammalian cation channels

Article Abstract:

A depolarizing, mixed Na+/K+ current, Ih, controls pacemaker activity of spontaneously active neurons. Ih also participates in the determination of the resting membrane potential of neurons. Ih is increased by hormones and neurotransmitters, via a mechanism independent of protein phosphorylation. The molecular cloning and function expression of the gene encoding a hyperpolarization-activated cation channel (HAC1) in the brain and heart, is reported. The channel shows the general properties of Ih channels.

Physiological aspects, Observations, Neurons, Cardiac pacing

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Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors

Article Abstract:

Glutamic-acid-rich proteins (GARPs) exist as GARP1 and GARP2, and as a large cytoplasmic domain of the beta-subunit of the cyclic GMP-gated channel. GARPs have been identified as multivalent proteins interacting with those involved in cGMP signalling, phosphodiesterase and guanylate cyclase, and with a retina-specific ATP-binding cassette transporter.

Research, Proteins, Photoreceptors

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