A frequency-dependent switch from inhibition to excitation in a hippocampal unitary circuit
Article Abstract:
The hippocampus, a brain structure essential for memory and cognition, is classically represented as a trisynaptic excitatory circuit. It is shown by recording from connected cell pairs in rat entorhinal-hippocampal slice cultures, that single action potentials in a dentate granule cell evoke a net inhibitory signal in a pyramidal cell. The ability to immediately switch the polarity of synaptic responses constitutes a novel synaptic mechanism, which might be crucial to the state-dependent processing of information in associative hippocampal networks.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Role for a cortical input to hippocampal area CA1 in the consolidation of a long-term memory
Article Abstract:
Stereotaxic coordinates to target the temporoammonic (TA) axons for electrolytic ablation are identified to assess the role of the TA pathway in the acquisition and retention of spatial memory in the rat. Findings reveal that after learning, ongoing cortical input conveyed by the TA path is required to consolidate long-term spatial memory.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3
Article Abstract:
The interconnection of CA1 and CA3 regions of the brain is investigated. A functional heterogeneity between the place cells of CA3 and CA1 at the level of neutral population representations is demonstrated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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