A license for duplication

Article Abstract:

Genome stability in animal cells necessitates strict control over the numbers of the organelles called centrosomes, which organize the construction and maintenance of the microtubule cytoskeleton that confers shape and polarity on the cell. An attractive 'licensing model' that explains how Centro some duplication is restricted to just once per cell cycle is presented.

Germany, Analysis, Genetic regulation, Genomes, Cell division, Structure

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Cell cycle regulation of central spindle assembly

Article Abstract:

A regulatory mechanism that controls the timing of the cell cycle regulation of the central spindle assembly is described. It is seen that the central spindle assembly occurs at the appropriate time in the cell cycle and maintains genomic stability due to the phosphoregulation of the motor domain of MKLP1 kinesin.

United States, Cell cycle, Spindle (Cell division), Spindle (Cytoplasm)

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Proteomic characterization of the human centrome by protein correlation profiling

Article Abstract:

A mass-spectrometry-based protemic analysis of human centrosomes in the interphase of the cell cycle by profiling proteins quantitatively. True centrosomal proteins were revealed by both correlation with already known centrosomal proteins and in vivo localization.

Proteomics

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