A sense of something missing

Article Abstract:

The hypothesis that the lysing of tumor cells by natural killer (NK) cells is impaired when the NK receptor Ly-49 is involved with major histocompatibility complex (MHC) class I molecules on the target cell received new support from research results by F.M. Karlhofer and colleagues. They ascertained Ly-49's role by testing Ly-49+ and Ly-49- on several tumor target cells; MHC genotype was strongly correlated with the effect of Ly-49+ on the tumor cells. In addition, W. Storkus and colleagues found that the peptide-binding groove of class I MHC molecules is involved in recognition by NK cells.

Models, Physiological aspects, Cell-mediated cytotoxicity, Cell mediated cytotoxicity, Cancer cells, Killer cells

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Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells

Article Abstract:

Allelic exclusion of Ly49 genes probably involves a mechanism that is different from that used by B and T lymphocytes and may play an important role in the genesis of a putative natural killer (NK)-cell receptor that is specific for class I molecules. NK-cell activity causes lysis of cells that stop expression of all or some of Class I major histocompatibility (MHC) molecules. Ly49A and Ly49C expression have a specificity for MHC and they are subject to allelic exclusion by NK-cell receptors.

Observations, Genetic regulation, Allelomorphism, Alleles

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Selection is not required to produce invariant T-cell receptor gamma-gene junctional sequences

Article Abstract:

The hypothesis that thymic selection operating on a population of originally diverse progenitor cells contributes to invariant junctional sequences in T-cell antigen receptors (TCR) was tested. Mutated TCR gamma-gene rearrangement substrates were intorduced into mice as transgenes. The results indicate that the canonical TCR Vgamma3-Jgamma1 and Vgamma4-Jgamma1 sequences occur at high frequency in the absence of the possibility selection for the protein products.

Antigen receptors, T cell, T cell antigen receptors, T cells, Junctional complexes (Epithelium)

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