A tale of two families

Article Abstract:

Genetic control of glutamate transporters differs from that of the other neurotransmitter transporters. Glutamate transporters consist of the glial and neuronal uptake systems that limit the secretion of glutamate by the most commonly occurring group of excitatory synapses. Three research groups - T. Storck and colleagues, Gilia Pines and colleagues and Yoshikatsu Kanai and Matthias A. Hediger - each cloned forms of complementary DNA that are the glutamate transporters' genetic carriers. In addition, Muriel Bouvier and colleagues found that glutamate transport affects extra- and intracellular pH.

Genetic aspects, Glutamate, Neurotransmitters

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Functional contributions of alpha5 subunit to neuronal acetycholine receptor channels

Article Abstract:

Ligand-gated ion channels are made of a combination of subunit complexes with each subunit-type being encoded by a number of related genes. Heterologous expression of any of the neuronal nicotinic acetylcholine receptors (nAChR) alpha-type subunits usually gives functional nAChR channels. It is shown that alpha5 is involved in nAChRs of heterologous systems and in primary neurons and plays a part in the lining of functionally unique nAChR channels.

Analysis, Ligands (Biochemistry), Ion channels

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Differential notch signalling distinguishes neural stem cells from intermediate progenitors

Article Abstract:

The signalling effects, which differentiate between neural stem cells and intermediate neural progenitors is studied. Findings indicate that neural stem cells and intermediate neural progenitors respond to Notch receptor activation.

Science & research, Operons, Stem cell research, Report

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