A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

Article Abstract:

Dorsal root ganglion sensory neurons show an unusual voltage-gated sodium channel resistant to tetrodotoxin. These cells also have a 1,957 amino-acid sodium channel that is identical by at least 65% with the rat cardiac tetrodotoxin-insensitive sodium channel. This is not shown in other peripheral and central neurons, glia or non-neuronal tissues. The channel is expressed by small-diameter sensory neurons in neonatal and adult dorsal root and trigeminal ganglia. Such C-fiber restricted sodium channel may possess a selective analgesic effect.

Tetrodotoxin, Neurophysiology

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A P2X purinoceptor expressed by a subset of sensory neurons

Article Abstract:

Molecular cloning and characterization of P2X(sub 3), belonging to the P2X family of receptors, reveals significant selectivity of expression and a pharmacology which may enable the transduction of ATP-initiated nociceptor activation. P2X(sub 3) is the sole known ligand-gated channel that is expressed by small sensory neurons. The pain-causing activity of ATP and the analgesic function of suramin due to P2X(sub 3) activation is discussed.

Usage, Cloning, Neural receptors

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Sensory neuron sodium channel [Na.sub.v]1.8 is essential for pain at low temperatures

Article Abstract:

A set of data results which provides strong evidence for a specialized role of [Na.sub.v]1.8 in nociceptors as the critical molecule for the perception of cold pain and pain in the cold is presented.

United States, Health aspects, Causes of, Headache, Nociceptors

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