Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice
Article Abstract:
B-cell memory and affinity maturation is independent of the presence of germinal centres in lymphotoxin-alpha-deficient mice. Low dose of T-cell-dependent antigen (4-hydroxy-3-nitrophenyl) acetyl-ovalbumin (NP-OVA) immunization shows deficient high-affinity anti-NP IgG1 production. High dose immunization results in high-affinity anti-NP IgGI production similar to that in wild-type mice, despite inability to produce germinal centres. Multiple high dose immunization reveals somatic mutations in anti-NP VH gene segment V(sub H)186.2, which are typical of affinity maturation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Increased bone formation in osteocalcin-deficient mice
Article Abstract:
Osteocalcin-deficient mice develop a phenotype with bones of higher mass and better functional quality. Histomorphometric analysis of these mice, before and after ovariectomy, reveals increased bone formation without any alteration in bone resorption or mineralization. The functional molecular mechanism for osteocalcin-controlled bone matrix deposition is unknown. Osteocalcin is a non-collagenous protein that binds to a specific receptor and functions as a negative controler of bone formation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Urinary odour preference in mice
Article Abstract:
Research is presented describing the study of mice and genetic factors which makes them prefer the smell of urine from unrelated mice rather than directly related animals.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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