Allele-specific replication timing of imprinted gene regions
Article Abstract:
Imprinted genes appear to be embedded in large DNA domains with different replication patterns. These patterns may provide a structural imprint for parental identity. Replication timing patterns for the chromosomal regions containing the imprinted genes Igf2, Igf2r, H19 and Snrpn in the mouse were examined in order to find the relationship between timing patterns and parental-specific transcription. The two homologous alleles replicate asynchronously at all of these sites, and it is always the paternal allele that is early-replicating.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Asynchronous replication of imprinted genes is established in the gametes and maintained during development
Article Abstract:
Differential replication timing is shown to be linked to imprinted genes in several cell types and is present in the pre-implantation embryo following fertilization. Asynchronous replication timing is established in the gametes, and maintained during developement, suggesting a function as an epigenetic market to distinguish between parental alleles.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Positive darwinian selection at the imprinted MEDEA locus in plants
Article Abstract:
MEDEA (MEA), the imprinted plant gene that originated during the whole-genome duplication is found to be of great significance for the development of seeds in plants. The analysis shows that MEA undergoes positive darwinian selection consistent with neo-functionalization after its duplication.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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