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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

An aminoacyl tRNA synthetase whose sequence fits into neither of the two known classes

Article Abstract:

Research into aminoacyl transfer RNA synthetases is described. It is shown that MJ1477 and its homologues are the first tRNA synthases whose sequences do not fit into the two known classes of synthases.

Author: Fabrega, Carme, Farrow, Mark A., Mukhopadhyay, Biswarup, Crecy-Lagard, Valerie de, Ortiz, Angel R., Schimmel, Paul
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Letter to the Editor

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Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration

Article Abstract:

The mouse sticky mutation, which causes cerebellar Purkinje cell loss and ataxia, is a missense mutation in the editing domain of the alanyl-transfer RNAs (tRNAs) is reported. The results have shown that disruption of translational fidelity in terminally differentiated neurons have led to the accumulation of misfolded proteins and cell death, and have provided a novel mechanism underlying neurodegeneration.

Author: Sundberg, John P., Schimmel, Paul, Davisson, Muriel T., Beebe, Kirk, Jeong Woong Lee, Nangle, Leslie A., Jang, Jaeseon, Longo-Guess, Chantal M., Cook, Susan A., Ackerman, Susan L.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
United States, Gene mutations, Gene mutation, Cell death, Ataxia

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Distinct domains of tRNA synthetase recognize the same base pair

Article Abstract:

The prevention of the synthesis of proteins with errors by the aminoacyl transfer RNA synthetases is discussed. The analysis shows that the same base pair is recognized by the different domains of a tRNA synthetase.

Author: Schimmel, Paul, Beebe, Kirk, Mock, Marissa, Merriman, Eve
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
Protein synthesis, Protein biosynthesis

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Subjects list: Research, Aminoacyl-tRNA synthetases, Transfer RNA
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