An anchor for activation

Article Abstract:

Transforming growth factor (TGF)-beta family members can transmits signals to the nucleus via a mixture of serine/threonine kinase receptors and Smads, their downstream effectors. Tsukazaki and colleagues have reported how the first intracellular stage in the TGC-beta/Smad pathway occurs, and identified an anchor protein, Smad anchor for receptor activation (SARA). They show that the subcellular localization of SARA is regulated by the FYVE domain, possibly through membrane-associated PtdIns(3)P.

Cellular signal transduction

---

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

Article Abstract:

The TGF-beta family of signalling molecules is involved in a wide range of biological activities. A new study shows that, in a homologous signalling pathway in Drosophila, the inhibitory SMAD is a product of the Daughters against decapentaplegic (Dad) gene, whose transcription is regulated by the TGF-beta family member, Drosophila Decapentaplegicoption (Dpp). Overexpression of Dad is shown to inhibit Dpp activity. Details of the study are presented.

Observations, Proteins, Morphogenesis, Transforming growth factors, Cell research, Cytological research

---

Similar abstracts:

• Abstracts: Asymmetric segregation of the homeodomain protein Prospero during Drosophila development. Making one cell from two
• Abstracts: Human leptin characterization. Acute stimulation of glucose metabolism in mice by leptin treatment. Leptin and the regulation of body weight in mammals
• Abstracts: Fringe-dependent separation of dorsal and ventral cells in the Drosophila wing. Fringe is glycosyltransferase that modifies Notch
• Abstracts: Projection structure of rhodopsin. Observations of light-induced structural changes of retinal within rhodopsin
• Abstracts: Backing for anti-cloning bill reopens embryo debate. Seed sows further doubts on cloning: Plans by a Chicago embryologist to clone a human being have renewed pressure for swift action to ban the practice in the United States

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.